What Is Leptin? The Master Hormone That Controls Energy and Weight

by Joanne

in Nutrition and Diets, Weight Loss

If you’re fat, anorexic, or diabetic, if you have low energy, if you have bone loss, if you’re a woman with amenorrhea or problems conceiving, you are probably leptin resistant.

Leptin is the master hormone that controls energy within the body. It is produced by our fat cells and taken up in the hypothalamus. Leptin lets your hypothalamus know how much energy you’ve consumed, and the hypothalamus then controls several other hormones based on leptin’s message. Proper leptin function tells our brain the energy status of our body in real time.

If leptin is off, every single hormonal response of the brain is off… When you’re leptin resistant, it’s like throwing mud on your windshield and driving on the Long Island Expressway. The brain has no way of knowing precisely what is going on in those 20 trillion cells. — Dr. Jack Kruse

Following a torn knee meniscus, Dr. Jack Kruse began studying leptin, spending 18 months and reading 5 to 6,000 articles. Implementing a plan he developed to work with his body’s circadian rhythms, he lost 77 pounds within the first 7 months and 133 pounds after 11 months. According to Jack, obesity is not a macronutrient story but a result of leptin resistance. In this interview he reveals:

  • How leptin plays a critical role in disease, health and wellness
  • Why obesity is an inflammatory brain condition
  • Why calories don’t matter when you’re leptin sensitive
  • How to eat in harmony with circadian rhythms
  • Factors that prevent uptake of leptin in the brain
  • Which fats contribute to leptin resistance
  • How low magnesium affects metabolic derangement
  • The best time of day to exercise
  • Why Michael Phelps can eat 18,000 calories per day and not gain weight
  • The importance of properly functioning uncoupling proteins
  • How low thyroid T3 prevents uncoupling proteins from working
  • How leptin resistance leads to infertility and osteoporosis
  • Why meal timing and composition are important in healing leptin resistance
  • Why you shouldn’t snack after dinner
  • How to become leptin sensitive, lose weight and improve your health

Total time: 105 minutes.


Click to listen to part 1 of this interview or right-click to download MP3 file

Click to listen to part 2 of this interview or right-click to download MP3 file


Dr. Jack KruseDr. Jack Kruse is a neurosurgeon who understands that in order to live pain free, one must take his or her health seriously at every level. His extensive medical training combined with his passion for wellness and nutrition has led to Dr. Kruse’s position as CEO of Optimized Life, a health and wellness company to help people avoid the common healthcare burdens that come with age. Dr. Kruse is also a member of the Age Management Medicine Group (AMMG).

Links in Interview

Jack’s Leptin Prescription
Hormones 101: Clinical Thoughts Revealed
The Leptin RX FAQ
Ramachandran TED talk on phantom pain
Mark’s Daily Apple Leptin Reset Experiment Forum Discussion
Robb Wolf’s The Paleo Solution Book
Mark Sisson’s The Primal Blueprint Book
Art De Vany’s The New Evolution Diet Book
Ron Rosedale’s The Rosedale Diet Book
Ancestral Health Symposium

{ 14 comments… read them below or add one }


I login, click on the link but it says it’s only for paid membership. I have free membership, how much is the paid?


Sorry! You do not have access to this content:


Sorry, this is premium content available only to paid members.

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thanks for sharing this, very interesting and crucial info! i’ve struggled with slightly elevated blood sugar for years, putting me in the “pre-diabetic” range. i’ve been gluten free for awhile, but am still eating too many carbs i’m sure.


@Ben. I’m not sure why you got that message. I got the message that your account was locked because it was being accessed from too many different locations. I have unlocked your account. Please try again.

@Susan. Glad you liked it. It’s not too late to turn your “pre-diabetes” around and get normal blood sugar levels. This leptin reset diet is a good start.

Jonathan Swaringen

I’d love to get a good quality copy of this to give to people…the ones on the website have audio artifacts for me. I’m not sure why maybe my player or the stream is just bad quality. Is there a place to get a better source for this? I have a coworker that could really use this. She may not understand it all but I think an audio recording would be very good.

She doesn’t have the internet so I gave her the Paleo Solution by Robb Wolf but listening can be easier than reading.


Thanks for activating my account…now I’m in. The interview with Jack Kruse was fabulous.



Awesome interview, I just found it. I have been eating Paleo for the last 4 years and have heard everyones explanation on why we become fat from Taubes to Sisson and everyone in between. I really believe Dr. Kruse has the best understanding the leptin role in obesity/weight gain of anyone. Cortisol and leptin are much more important than insulin in my view. You really did a great job in the interview, and Dr. Jack broke down the mechanics that anyone can understand. He is a saint to put out this kind of information for free.


Glad you folks liked the interview. I really enjoyed it myself. I kept waiting for him to say he had to go, but he just kept answering my questions. It was great.


Just listened to this. Great interview, but, I’m still a little confused. I guess I need to listen a few more times and/or go study his website. Joanne, did you implement any of Jack’s recommendations? I hope you’re feeling better.

Thanks for putting this great information out there.



Thanks, J. Yes, by all means visit his site. He has instructions on how to implement his diet.

My focus right now is on eliminating foods to which I’m allergic. Very hard for me given my addictive nature. I did start eating breakfast, which is a big change. But I have trouble sticking to it.


Hi Joanne,

I’ve been trying the breakfast/mega protein in the am thing, too. Very challenging. But, still trying.

Good luck!



tried to log on, got accepted but the link does nto work and rejects me. If you are adbvertising that you are hosting interview tih Dr Kruse,you should allow people access as you advertise. Otherwise, it seems rather dishonest.


Ekllie, why so quick to assume something sinister? Your account is active and I resent your password to you. The password is case-sensitive. Please try again.


thank you, in y defense I tried many times over the weekend and it is only today that I ssucceded.


Hello there,
just offering a suggestion in case you see it useful: I suggest to put the date of the Podcast somewhere at the top of the page.
thanks very much for intervieweing Dr Kruse.

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